Stromal cues regulate the pancreatic cancer epigenome and metabolome

A fibroinflammatory stromal reaction cooperates with oncogenic signaling to influence pancreatic ductal adenocarcinoma (PDAC) initiation, progression, and therapeutic outcome, yet the mechanistic underpinning of this crosstalk remains poorly understood. Here we show that stromal cues elicit an adapt...

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Dades bibliogràfiques
Publicat a:Proc Natl Acad Sci U S A
Autors principals: Sherman, Mara H., Yu, Ruth T., Tseng, Tiffany W., Sousa, Cristovao M., Liu, Sihao, Truitt, Morgan L., He, Nanhai, Ding, Ning, Liddle, Christopher, Atkins, Annette R., Leblanc, Mathias, Collisson, Eric A., Asara, John M., Kimmelman, Alec C., Downes, Michael, Evans, Ronald M.
Format: Artigo
Idioma:Inglês
Publicat: National Academy of Sciences 2017
Matèries:
Biological Sciences
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC5293019/
https://ncbi.nlm.nih.gov/pubmed/28096419
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1620164114
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