Association of a Novel Human Immunodeficiency Virus Type 1 Protease Substrate Cleft Mutation, L23I, with Protease Inhibitor Therapy and In Vitro Drug Resistance

We observed a previously uncharacterized mutation in the protease substrate cleft, L23I, in 31 of 4,303 persons undergoing human immunodeficiency virus type 1 genotypic resistance testing. In combination with V82I, L23I was associated with a sevenfold reduction in nelfinavir susceptibility and a dec...

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Bibliographic Details
Main Authors: Johnston, Elizabeth, Winters, Mark A., Rhee, Soo-Yon, Merigan, Thomas C., Schiffer, Celia A., Shafer, Robert W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2004
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC529213/
https://ncbi.nlm.nih.gov/pubmed/15561868
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.12.4864-4868.2004
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