A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells

Direct cell programming via overexpression of transcription factors (TFs) aims to control cell fate with the degree of precision needed for clinical applications. However, the regulatory steps involved in successful terminal cell fate programming remain obscure. We have investigated the underlying m...

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Veröffentlicht in:Cell Stem Cell
Hauptverfasser: Velasco, Silvia, Ibrahim, Mahmoud M, Kakumanu, Akshay, Garipler, Görkem, Aydin, Begüm, Al-Sayegh, Mohamed Ahmed, Hirsekorn, Antje, Abdul-Rahman, Farah, Satija, Rahul, Ohler, Uwe, Mahony, Shaun, Mazzoni, Esteban O
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291817/
https://ncbi.nlm.nih.gov/pubmed/27939218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.11.006
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