A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells

Direct cell programming via overexpression of transcription factors (TFs) aims to control cell fate with the degree of precision needed for clinical applications. However, the regulatory steps involved in successful terminal cell fate programming remain obscure. We have investigated the underlying m...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Velasco, Silvia, Ibrahim, Mahmoud M, Kakumanu, Akshay, Garipler, Görkem, Aydin, Begüm, Al-Sayegh, Mohamed Ahmed, Hirsekorn, Antje, Abdul-Rahman, Farah, Satija, Rahul, Ohler, Uwe, Mahony, Shaun, Mazzoni, Esteban O
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291817/
https://ncbi.nlm.nih.gov/pubmed/27939218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.11.006
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