A multi-step transcriptional and chromatin state cascade underlies motor neuron programming from embryonic stem cells

Direct cell programming via overexpression of transcription factors (TFs) aims to control cell fate with the degree of precision needed for clinical applications. However, the regulatory steps involved in successful terminal cell fate programming remain obscure. We have investigated the underlying m...

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Udgivet i:Cell Stem Cell
Main Authors: Velasco, Silvia, Ibrahim, Mahmoud M, Kakumanu, Akshay, Garipler, Görkem, Aydin, Begüm, Al-Sayegh, Mohamed Ahmed, Hirsekorn, Antje, Abdul-Rahman, Farah, Satija, Rahul, Ohler, Uwe, Mahony, Shaun, Mazzoni, Esteban O
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291817/
https://ncbi.nlm.nih.gov/pubmed/27939218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.11.006
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