Development of Cell‐Permeable, Non‐Helical Constrained Peptides to Target a Key Protein–Protein Interaction in Ovarian Cancer

There is a lack of current treatment options for ovarian clear cell carcinoma (CCC) and the cancer is often resistant to platinum‐based chemotherapy. Hence there is an urgent need for novel therapeutics. The transcription factor hepatocyte nuclear factor 1β (HNF1β) is ubiquitously overexpressed in C...

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Vydáno v:Angew Chem Int Ed Engl
Hlavní autoři: Wiedmann, Mareike M., Tan, Yaw Sing, Wu, Yuteng, Aibara, Shintaro, Xu, Wenshu, Sore, Hannah F., Verma, Chandra S., Itzhaki, Laura, Stewart, Murray, Brenton, James D., Spring, David R.
Médium: Artigo
Jazyk:Inglês
Vydáno: John Wiley and Sons Inc. 2016
Témata:
Communications
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291322/
https://ncbi.nlm.nih.gov/pubmed/27918136
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/anie.201609427
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