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Prophylactic efficacy of BeneFIX vs Alprolix in hemophilia B mice

FIX binds tightly to collagen IV. Furthermore, a FIX mutant, FIX(K5R), which binds better than wild-type FIX to collagen IV, provides better hemostasis than wild-type FIX, long after both are undetectable in the plasma. There is also credible evidence of extravascular FIX. Here, we use the saphenous...

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Detalhes bibliográficos
Publicado no:Blood
Main Authors: Cooley, Brian, Funkhouser, William, Monroe, Dougald, Ezzell, Ashley, Mann, David M., Lin, Feng-Chang, Monahan, Paul E., Stafford, Darrel W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society of Hematology 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5291301/
https://ncbi.nlm.nih.gov/pubmed/27106122
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2016-01-696104
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