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FVIIa as used pharmacologically is not TF dependent in hemophilia B mice

Activated factor VII is approved for treating hemophilia patients with autoantibodies to their factor IX or FVIII; however, its mechanism of action remains controversial. Some studies suggest that FVIIa requires tissue factor (TF) for function and that the reason for the high dose requirement is tha...

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Autores principales: Feng, Dengmin, Whinna, Herbert, Monroe, Dougald, Stafford, Darrel W.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society of Hematology 2014
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3954056/
https://ncbi.nlm.nih.gov/pubmed/24425804
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2013-08-522987
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