Evaluation of the Role of Constitutive Isocitrate Lyase Activity in Yersinia pestis Infection of the Flea Vector and Mammalian Host

Yersinia pestis, unlike the closely related Yersinia pseudotuberculosis, constitutively produces isocitrate lyase (ICL). Here we show that the Y. pestis aceA homologue encodes ICL and is required for growth on acetate but not for flea infection or virulence in mice. Thus, deregulation of the glyoxyl...

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Bibliografiske detaljer
Main Authors: Sebbane, Florent, Jarrett, Clayton O., Linkenhoker, Jan R., Hinnebusch, B. Joseph
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2004
Fag:
Molecular Pathogenesis
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC529124/
https://ncbi.nlm.nih.gov/pubmed/15557663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.7334-7337.2004
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