Evaluation of the Role of Constitutive Isocitrate Lyase Activity in Yersinia pestis Infection of the Flea Vector and Mammalian Host

Yersinia pestis, unlike the closely related Yersinia pseudotuberculosis, constitutively produces isocitrate lyase (ICL). Here we show that the Y. pestis aceA homologue encodes ICL and is required for growth on acetate but not for flea infection or virulence in mice. Thus, deregulation of the glyoxyl...

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Hlavní autoři: Sebbane, Florent, Jarrett, Clayton O., Linkenhoker, Jan R., Hinnebusch, B. Joseph
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2004
Témata:
Molecular Pathogenesis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC529124/
https://ncbi.nlm.nih.gov/pubmed/15557663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.72.12.7334-7337.2004
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