Evaluation of the Role of Constitutive Isocitrate Lyase Activity in Yersinia pestis Infection of the Flea Vector and Mammalian Host

Yersinia pestis, unlike the closely related Yersinia pseudotuberculosis, constitutively produces isocitrate lyase (ICL). Here we show that the Y. pestis aceA homologue encodes ICL and is required for growth on acetate but not for flea infection or virulence in mice. Thus, deregulation of the glyoxyl...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Sebbane, Florent, Jarrett, Clayton O., Linkenhoker, Jan R., Hinnebusch, B. Joseph
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2004
Assuntos:	Molecular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC529124/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15557663/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/IAI.72.12.7334-7337.2004
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