A Novel Motif for S-Adenosyl-l-methionine Binding by the Ribosomal RNA Methyltransferase TlyA from Mycobacterium tuberculosis

Capreomycin is a potent ribosome-targeting antibiotic that is an essential component of current antituberculosis treatments, particularly in the case of multidrug-resistant Mycobacterium tuberculosis (Mtb). Optimal capreomycin binding and Mtb ribosome inhibition requires ribosomal RNA methylation in...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Witek, Marta A., Kuiper, Emily G., Minten, Elizabeth, Crispell, Emily K., Conn, Graeme L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2017
Assuntos:
Protein Structure and Folding
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290967/
https://ncbi.nlm.nih.gov/pubmed/28031456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.752659
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