Functional Roles in S-Adenosyl-L-Methionine Binding and Catalysis for Active Site Residues of the Thiostrepton Resistance Methyltransferase

Resistance to the antibiotic thiostrepton, in producing Streptomycetes, is conferred by the S-adenosyl-l-methionine (SAM)-dependent SPOUT methyltransferase Tsr. For this and related enzymes, the roles of active site amino acids have been inadequately described. Herein, we have probed SAM interaction...

Full beskrivning

Sparad:
Bibliografiska uppgifter
I publikationen:FEBS Lett
Huvudupphovsmän: Myers, Cullen L., Kuiper, Emily G., Grant, Pei C., Hernandez, Jennifer, Conn, Graeme L., Honek, John F.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2015
Ämnen:
Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661090/
https://ncbi.nlm.nih.gov/pubmed/26450779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.09.028
Taggar: Lägg till en tagg
Inga taggar, Lägg till första taggen!

Liknande verk