Functional Roles in S-Adenosyl-L-Methionine Binding and Catalysis for Active Site Residues of the Thiostrepton Resistance Methyltransferase

Resistance to the antibiotic thiostrepton, in producing Streptomycetes, is conferred by the S-adenosyl-l-methionine (SAM)-dependent SPOUT methyltransferase Tsr. For this and related enzymes, the roles of active site amino acids have been inadequately described. Herein, we have probed SAM interaction...

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Publicado en:FEBS Lett
Main Authors: Myers, Cullen L., Kuiper, Emily G., Grant, Pei C., Hernandez, Jennifer, Conn, Graeme L., Honek, John F.
Formato: Artigo
Idioma:Inglês
Publicado: 2015
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4661090/
https://ncbi.nlm.nih.gov/pubmed/26450779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2015.09.028
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