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Autophagy-mediated Regulation of BACE1 Protein Trafficking and Degradation
β-Site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the major neuronal β-secretase for amyloid-β generation and is degraded in lysosomes. The autophagy-lysosomal system plays a key role in the maintenance of cellular homeostasis in neurons. Recent studies established that nascent aut...
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| Udgivet i: | J Biol Chem |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American Society for Biochemistry and Molecular Biology
2017
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5290944/ https://ncbi.nlm.nih.gov/pubmed/28028177 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M116.766584 |
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