Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease

Amyloid-β (Aβ) peptides play a key role in synaptic damage and memory deficits in the early pathogenesis of Alzheimer's disease (AD). Abnormal accumulation of Aβ at nerve terminals leads to synaptic pathology and ultimately to neurodegeneration. β-site amyloid precursor protein (APP) cleaving e...

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Bibliografiske detaljer
Udgivet i:J Neurosci
Main Authors: Ye, Xuan, Feng, Tuancheng, Tammineni, Prasad, Chang, Qing, Jeong, Yu Young, Margolis, David J., Cai, Huaibin, Kusnecov, Alexander, Cai, Qian
Format: Artigo
Sprog:Inglês
Udgivet: Society for Neuroscience 2017
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354320/
https://ncbi.nlm.nih.gov/pubmed/28159908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2851-16.2017
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