Regulation of Synaptic Amyloid-β Generation through BACE1 Retrograde Transport in a Mouse Model of Alzheimer's Disease

Amyloid-β (Aβ) peptides play a key role in synaptic damage and memory deficits in the early pathogenesis of Alzheimer's disease (AD). Abnormal accumulation of Aβ at nerve terminals leads to synaptic pathology and ultimately to neurodegeneration. β-site amyloid precursor protein (APP) cleaving e...

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Detalhes bibliográficos
Publicado no:J Neurosci
Main Authors: Ye, Xuan, Feng, Tuancheng, Tammineni, Prasad, Chang, Qing, Jeong, Yu Young, Margolis, David J., Cai, Huaibin, Kusnecov, Alexander, Cai, Qian
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2017
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5354320/
https://ncbi.nlm.nih.gov/pubmed/28159908
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2851-16.2017
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