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Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons
Lysosomal proteolysis is essential for the quality control of intracellular components and the maintenance of cellular homeostasis. Lysosomal alterations have been implicated as one of the main cellular defects contributing to the onset and progression of Alzheimer’s disease (AD). However, the mecha...
Guardat en:
| Publicat a: | Hum Mol Genet |
|---|---|
| Autors principals: | , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
Oxford University Press
2017
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886073/ https://ncbi.nlm.nih.gov/pubmed/28973312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx321 |
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