Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons

Lysosomal proteolysis is essential for the quality control of intracellular components and the maintenance of cellular homeostasis. Lysosomal alterations have been implicated as one of the main cellular defects contributing to the onset and progression of Alzheimer’s disease (AD). However, the mecha...

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Bibliographic Details
Published in:Hum Mol Genet
Main Authors: Tammineni, Prasad, Jeong, Yu Young, Feng, Tuancheng, Aikal, Daniyal, Cai, Qian
Format: Artigo
Language:Inglês
Published: Oxford University Press 2017
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5886073/
https://ncbi.nlm.nih.gov/pubmed/28973312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx321
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