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Impaired axonal retrograde trafficking of the retromer complex augments lysosomal deficits in Alzheimer’s disease neurons
Lysosomal proteolysis is essential for the quality control of intracellular components and the maintenance of cellular homeostasis. Lysosomal alterations have been implicated as one of the main cellular defects contributing to the onset and progression of Alzheimer’s disease (AD). However, the mecha...
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| Published in: | Hum Mol Genet |
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| Main Authors: | , , , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
Oxford University Press
2017
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5886073/ https://ncbi.nlm.nih.gov/pubmed/28973312 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddx321 |
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