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Snapin-Mediated BACE1 Retrograde Transport Is Essential for its Degradation in Lysosomes and Regulation of APP Processing in Neurons
β-site amyloid precursor protein (APP) cleaving enzyme 1 (BACE1) is the major β-secretase for generating amyloid-β (Aβ) peptides. The acidic environment of endosomes is optimal for β-secretase activity. However, the mechanisms regulating BACE1 traffic from endosomes to lysosomes for degradation are...
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| Main Authors: | , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2013
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3905048/ https://ncbi.nlm.nih.gov/pubmed/24373968 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.12.008 |
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