Promoting Cas9 degradation reduces mosaic mutations in non-human primate embryos

CRISPR-Cas9 is a powerful new tool for genome editing, but this technique creates mosaic mutations that affect the efficiency and precision of its ability to edit the genome. Reducing mosaic mutations is particularly important for gene therapy and precision genome editing. Although the mechanisms un...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Tu, Zhuchi, Yang, Weili, Yan, Sen, Yin, An, Gao, Jinquan, Liu, Xudong, Zheng, Yinghui, Zheng, Jiezhao, Li, Zhujun, Yang, Su, Li, Shihua, Guo, Xiangyu, Li, Xiao-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5290468/
https://ncbi.nlm.nih.gov/pubmed/28155910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep42081
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