Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9

CRISPR/Cas9 has been used to genetically modify genomes in a variety of species, including non-human primates. Unfortunately, this new technology does cause mosaic mutations, and we do not yet know whether such mutations can functionally disrupt the targeted gene or cause the pathology seen in human...

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Detalhes bibliográficos
Publicado no:Hum Mol Genet
Main Authors: Chen, Yongchang, Zheng, Yinghui, Kang, Yu, Yang, Weili, Niu, Yuyu, Guo, Xiangyu, Tu, Zhuchi, Si, Chenyang, Wang, Hong, Xing, Ruxiao, Pu, Xiuqiong, Yang, Shang-Hsun, Li, Shihua, Ji, Weizhi, Li, Xiao-Jiang
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2015
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5007610/
https://ncbi.nlm.nih.gov/pubmed/25859012
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddv120
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