Crystal structure of an LSD-bound human serotonin receptor

The prototypical hallucinogen LSD acts via serotonin receptors, and here we describe the crystal structure of LSD in complex with the human serotonin receptor 5-HT(2B). The complex reveals conformational rearrangements to accommodate LSD, providing a structural explanation for the conformational sel...

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Détails bibliographiques
Publié dans:Cell
Auteurs principaux: Wacker, Daniel, Wang, Sheng, McCorvy, John D., Betz, Robin M., Venkatakrishnan, A. J., Levit, Anat, Lansu, Katherine, Schools, Zachary L., Che, Tao, Nichols, David E., Shoichet, Brian K., Dror, Ron O., Roth, Bryan L.
Format: Artigo
Langue:Inglês
Publié: 2017
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC5289311/
https://ncbi.nlm.nih.gov/pubmed/28129538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cell.2016.12.033
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