Erg4A and Erg4B Are Required for Conidiation and Azole Resistance via Regulation of Ergosterol Biosynthesis in Aspergillus fumigatus

Ergosterol, a fungus-specific sterol enriched in cell plasma membranes, is an effective antifungal drug target. However, current knowledge of the ergosterol biosynthesis process in the saprophytic human fungal pathogen Aspergillus fumigatus remains limited. In this study, we found that two endoplasm...

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Bibliographic Details
Published in:Appl Environ Microbiol
Main Authors: Long, Nanbiao, Xu, Xiaoling, Zeng, Qiuqiong, Sang, Hong, Lu, Ling
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2017
Subjects:
Genetics and Molecular Biology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288824/
https://ncbi.nlm.nih.gov/pubmed/27986720
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.02924-16
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