TGF-β1 along with other platelet contents augments Treg cells to suppress anti-FVIII immune responses in hemophilia A mice

Platelets are a rich source of many cytokines and chemokines including transforming growth factor β 1 (TGF-β1). TGF-β1 is required to convert conventional CD4(+) T (Tconv) cells into induced regulatory T (iTreg) cells that express the transcription factor Foxp3. Whether platelet contents will affect...

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Vydáno v:Blood Adv
Hlavní autoři: Haribhai, Dipica, Luo, Xiaofeng, Chen, Juan, Jia, Shuang, Shi, Linzheng, Schroeder, Jocelyn A., Weiler, Hartmut, Aster, Richard H., Hessner, Martin J., Hu, Jianda, Williams, Calvin B., Shi, Qizhen
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society of Hematology 2016
Témata:
Thrombosis and Hemostasis
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288643/
https://ncbi.nlm.nih.gov/pubmed/28164173
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/bloodadvances.2016001453
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