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Chemoenzymatic synthesis of unmodified heparin oligosaccharides: Cleavage of p-nitrophenyl glucuronide by alkaline and Smith degradation

A heparin oligosaccharide having a completely natural structure was successfully synthesized through a chemoenzymatic approach using an unnatural glycosyl acceptor, p-nitrophenyl glucuronide (GlcA-pNP). The use of an inexpensive and commercially available GlcA-pNP acceptor facilitates oligosaccharid...

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Vydáno v:Org Biomol Chem
Hlavní autoři: Zhang, Xing, Xu, Yongmei, Hsieh, Po-Hung, Liu, Jian, Lin, Lei, Schmidt, Eric, Linhardt, Robert J.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2017
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5288288/
https://ncbi.nlm.nih.gov/pubmed/28091666
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1039/c6ob02603f
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