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Immunomodulation by memantine in therapy of Alzheimer's disease is mediated through inhibition of K(v)1.3 channels and T cell responsiveness
Memantine is approved for the treatment of advanced Alzheimer's disease (AD) and reduces glutamate-mediated neuronal excitotoxicity by antagonism of N-methyl-D-aspartate receptors. In the pathophysiology of AD immune responses deviate and infectious side effects are observed during memantine th...
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| Publicado no: | Oncotarget |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Impact Journals LLC
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5288222/ https://ncbi.nlm.nih.gov/pubmed/27462773 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.18632/oncotarget.10777 |
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