Immunosuppression by N-Methyl-d-Aspartate Receptor Antagonists Is Mediated through Inhibition of K(v)1.3 and K(Ca)3.1 Channels in T Cells

N-Methyl-d-aspartate receptors (NMDARs) are ligand-gated ion channels that play an important role in neuronal development, plasticity, and excitotoxicity. NMDAR antagonists are neuroprotective in animal models of neuronal diseases, and the NMDAR open-channel blocker memantine is used to treat Alzhei...

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Main Authors: Kahlfuß, Sascha, Simma, Narasimhulu, Mankiewicz, Judith, Bose, Tanima, Lowinus, Theresa, Klein-Hessling, Stefan, Sprengel, Rolf, Schraven, Burkhart, Heine, Martin, Bommhardt, Ursula
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2014
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4023824/
https://ncbi.nlm.nih.gov/pubmed/24344200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01273-13
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