Application of locked nucleic acids to improve aptamer in vivo stability and targeting function

Aptamers are powerful candidates for molecular imaging applications due to a number of attractive features, including rapid blood clearance and tumor penetration. We carried out structure–activity relationship (SAR) studies with the Tenascin-C binding aptamer TTA1, which is a promising candidate for...

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Détails bibliographiques
Publié dans:Nucleic Acids Res
Auteurs principaux: Schmidt, Kathrin S., Borkowski, Sandra, Kurreck, Jens, Stephens, Andrew W., Bald, Rolf, Hecht, Maren, Friebe, Matthias, Dinkelborg, Ludger, Erdmann, Volker A.
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2004
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Articles
Accès en ligne:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC528785/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15509871/
https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/gkh862
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