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Cytochrome b(5) activates the 17,20-lyase activity of human cytochrome P450 17A1 by increasing the coupling of NADPH consumption to androgen production
Human cytochrome P450 17A1 is required for all androgen biosynthesis and is the target of abiraterone, a drug used widely to treat advanced prostate cancer. P450 17A1 catalyzes both 17-hydroxylation and subsequent 17,20-lyase reactions with pregnenolone, progesterone and allopregnanolone. The presen...
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| Publié dans: | Biochemistry |
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| Auteurs principaux: | , , , , , , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
2016
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5287367/ https://ncbi.nlm.nih.gov/pubmed/27426448 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.6b00532 |
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