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Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation
The Ras signaling pathway plays a critical role in B lymphocyte development and activation, but its activation mechanism has not been well understood. At least one mode of Ras regulation in B cells involves a Ras-guanyl nucleotide exchange factor, RasGRP3. We demonstrate here that RasGRP3 undergoes...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
National Academy of Sciences
2004
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC528733/ https://ncbi.nlm.nih.gov/pubmed/15545601 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407468101 |
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