Activation of RasGRP3 by phosphorylation of Thr-133 is required for B cell receptor-mediated Ras activation

The Ras signaling pathway plays a critical role in B lymphocyte development and activation, but its activation mechanism has not been well understood. At least one mode of Ras regulation in B cells involves a Ras-guanyl nucleotide exchange factor, RasGRP3. We demonstrate here that RasGRP3 undergoes...

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Bibliografiske detaljer
Main Authors: Aiba, Yuichi, Oh-hora, Masatsugu, Kiyonaka, Shigeki, Kimura, Yayoi, Hijikata, Atsushi, Mori, Yasuo, Kurosaki, Tomohiro
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2004
Fag:
Biological Sciences
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC528733/
https://ncbi.nlm.nih.gov/pubmed/15545601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0407468101
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