Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

BACKGROUND: More than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew and increased the tumor proge...

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Pubblicato in:Mol Cancer
Autori principali: Chandrakesan, Parthasarathy, Yao, Jiannan, Qu, Dongfeng, May, Randal, Weygant, Nathaniel, Ge, Yang, Ali, Naushad, Sureban, Sripathi M., Gude, Modhi, Vega, Kenneth, Bannerman-Menson, Eddie, Xia, Lijun, Bronze, Michael, An, Guangyu, Houchen, Courtney W.
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2017
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286867/
https://ncbi.nlm.nih.gov/pubmed/28148261
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-017-0594-y
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