AAV1/2-induced overexpression of A53T-α-synuclein in the substantia nigra results in degeneration of the nigrostriatal system with Lewy-like pathology and motor impairment: a new mouse model for Parkinson’s disease

α-Synuclein is a protein implicated in the etiopathogenesis of Parkinson’s disease (PD). AAV1/2-driven overexpression of human mutated A53T-α-synuclein in rat and monkey substantia nigra (SN) induces degeneration of nigral dopaminergic neurons and decreases striatal dopamine and tyrosine hydroxylase...

Ful tanımlama

Kaydedildi:
Detaylı Bibliyografya
Yayımlandı:Acta Neuropathol Commun
Asıl Yazarlar: Ip, Chi Wang, Klaus, Laura-Christin, Karikari, Akua A., Visanji, Naomi P., Brotchie, Jonathan M., Lang, Anthony E., Volkmann, Jens, Koprich, James B.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2017
Konular:
Methodology Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5286802/
https://ncbi.nlm.nih.gov/pubmed/28143577
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-017-0416-x
Etiketler: Etiketle
Etiket eklenmemiş, İlk siz ekleyin!

Benzer Materyaller