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Lean body weight and metformin are insufficient to prevent endometrial hyperplasia in mice harboring inactivating mutations in PTEN
OBJECTIVES: Obesity is a major risk factor for endometrial cancer. We evaluated whether obesity exacerbates progression of endometrial hyperplasia (EH) using the PRCre/+ PTENflox/+ mouse model and examined if the type-2-diabetes drug, metformin, could prevent EH. METHODS: Twenty obese (PRCre/+ PTEN...
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| Publicado no: | Oncology |
|---|---|
| Main Authors: | , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5285472/ https://ncbi.nlm.nih.gov/pubmed/27931017 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000450615 |
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