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Ligand-stimulated signaling events in immature CD4+CD8+ thymocytes expressing competent T-cell receptor complexes.

During thymic selection of the developing T-cell repertoire, the fate of individual CD4+CD8+ thymocytes is determined by the specificity of the T-cell antigen receptors (TCRs) they express. Paradoxically, most CD4+CD8+ thymocytes express few TCR molecules, and those they express are essentially inca...

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Published in:Proc Natl Acad Sci U S A
Main Authors: Nakayama, T, Samelson, L E, Nakayama, Y, Munitz, T I, Sheard, M, June, C H, Singer, A
Format: Artigo
Language:Inglês
Published: National Academy of Sciences 1991
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Research Article
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52844/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1719558/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.22.9949
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