Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.

Eitemau Tebyg

• Subcellular localization of T-cell receptor complexes containing tyrosine-phosphorylated zeta proteins in immature CD4+CD8+ thymocytes.
  gan: Kearse, K P, et al.
  Cyhoeddwyd: (1993)
• Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways
  Cyhoeddwyd: (1989)
• Selective Regulation of TCR Signaling Pathways by the CD45 Protein Tyrosine Phosphatase During Thymocyte Development
  gan: Falahati, Rustom, et al.
  Cyhoeddwyd: (2008)
• Specific interaction of the CD45 protein-tyrosine phosphatase with tyrosine-phosphorylated CD3 zeta chain.
  gan: Furukawa, T, et al.
  Cyhoeddwyd: (1994)
• Decreased signaling competence as a result of receptor overexpression: overexpression of CD4 reduces its ability to activate p56lck tyrosine kinase and to regulate T-cell antigen receptor expression in immature CD4+CD8+ thymocytes.
  gan: Nakayama, T, et al.
  Cyhoeddwyd: (1993)