Engagement of the external domains of CD45 tyrosine phosphatase can regulate the differentiation of immature CD4+CD8+ thymocytes into mature T cells.

Immature precursor cells are induced in the thymus to express clonotypic T-cell antigen receptors (TCRs) and to differentiate into mature T cells. Perhaps the least understood event which occurs during intrathymic development is the positive selection of immature CD4+CD8+ thymocytes for differentiat...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Benveniste, P, Takahama, Y, Wiest, D L, Nakayama, T, Sharrow, S O, Singer, A
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC44312/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8041724/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.91.15.6933
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