Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production

STAT3 is a transcription factor implicated in renal fibrotic injury, but the role of STAT3 in mesenchymal stem cell (MSC)-induced renoprotection during renal fibrosis remains unknown. We hypothesized that MSCs protect against obstruction-induced renal fibrosis by downregulating STAT3 activation and...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Am J Physiol Renal Physiol
Autori principali: Matsui, Futoshi, Babitz, Stephen A., Rhee, Audrey, Hile, Karen L., Zhang, Hongji, Meldrum, Kirstan K.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Physiological Society 2017
Soggetti:
Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283885/
https://ncbi.nlm.nih.gov/pubmed/27760767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00311.2016
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi