Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production

STAT3 is a transcription factor implicated in renal fibrotic injury, but the role of STAT3 in mesenchymal stem cell (MSC)-induced renoprotection during renal fibrosis remains unknown. We hypothesized that MSCs protect against obstruction-induced renal fibrosis by downregulating STAT3 activation and...

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Detaylı Bibliyografya
Yayımlandı:Am J Physiol Renal Physiol
Asıl Yazarlar: Matsui, Futoshi, Babitz, Stephen A., Rhee, Audrey, Hile, Karen L., Zhang, Hongji, Meldrum, Kirstan K.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Physiological Society 2017
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283885/
https://ncbi.nlm.nih.gov/pubmed/27760767
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00311.2016
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