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SGK1-dependent ENaC processing and trafficking in mice with high dietary K intake and elevated aldosterone

We examined renal Na and K transporters in mice with deletions in the gene encoding the aldosterone-induced protein SGK1. The knockout mice were hyperkalemic, and had altered expression of the subunits of the epithelial Na channel (ENaC). The kidneys showed decreased expression of the cleaved forms...

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書目詳細資料
發表在:Am J Physiol Renal Physiol
Main Authors: Yang, Lei, Frindt, Gustavo, Lang, Florian, Kuhl, Dietmar, Vallon, Volker, Palmer, Lawrence G.
格式: Artigo
語言:Inglês
出版: American Physiological Society 2016
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283884/
https://ncbi.nlm.nih.gov/pubmed/27413200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00257.2016
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