Genome-wide screen of cell-cycle regulators in normal and tumor cells identifies a differential response to nucleosome depletion

To identify cell cycle regulators that enable cancer cells to replicate DNA and divide in an unrestricted manner, we performed a parallel genome-wide RNAi screen in normal and cancer cell lines. In addition to many shared regulators, we found that tumor and normal cells are differentially sensitive...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Sokolova, Maria, Turunen, Mikko, Mortusewicz, Oliver, Kivioja, Teemu, Herr, Patrick, Vähärautio, Anna, Björklund, Mikael, Taipale, Minna, Helleday, Thomas, Taipale, Jussi
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2016
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Report
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5283814/
https://ncbi.nlm.nih.gov/pubmed/27929715
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2016.1261765
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