Assessment of Protein Binding of 5-Hydroxythalidomide Bioactivated in Humanized Mice with Human P450 3A-chromosome or Hepatocytes by Two-dimensional Electrophoresis/Accelerator Mass Spectrometry

Bioactivation of 5-hydroxy-[carbonyl-(14)C]thalidomide, a known metabolite of thalidomide, by human artificial or native cytochrome P450 3A enzymes, and nonspecific binding in livers of mice was assessed using two-dimensional electrophoresis combined with accelerator mass spectrometry. The apparent...

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Gepubliceerd in:Chem Res Toxicol
Hoofdauteurs: Yamazaki, Hiroshi, Suemizu, Hiroshi, Kazuki, Yasuhiro, Oofusa, Ken, Kuribayashi, Shunji, Shimizu, Makiko, Ninomiya, Shinichi, Horie, Toru, Shibata, Norio, Guengerich, F. Peter
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2016
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282975/
https://ncbi.nlm.nih.gov/pubmed/27464947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.chemrestox.6b00210
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