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A fidelity mechanism in DNA polymerase lambda promotes error‐free bypass of 8‐oxo‐dG
8‐oxo‐7,8‐dihydroxy‐2′‐deoxyguanosine (8‐oxo‐dG) has high mutagenic potential as it is prone to mispair with deoxyadenine (dA). In order to maintain genomic integrity, post‐replicative 8‐oxo‐dG:dA mispairs are removed through DNA polymerase lambda (Pol λ)‐dependent MUTYH‐initiated base excision repa...
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| Udgivet i: | EMBO J |
|---|---|
| Main Authors: | , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
John Wiley and Sons Inc.
2016
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5282837/ https://ncbi.nlm.nih.gov/pubmed/27481934 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/embj.201694332 |
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