Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress

BACKGROUND: Progranulin (PGRN) has recently emerged as an important regulator for insulin resistance. However, the direct effect of progranulin in adipose insulin resistance associated with the autophagy mechanism is not fully understood. METHODS: In the present study, progranulin was administered t...

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Veröffentlicht in:Lipids Health Dis
Hauptverfasser: Guo, Qinyue, Xu, Lin, Li, Huixia, Sun, Hongzhi, Liu, Jiali, Wu, Shufang, Zhou, Bo
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2017
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282713/
https://ncbi.nlm.nih.gov/pubmed/28143512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-017-0425-6
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