Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN in vivo and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGRN fo...

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Detalhes bibliográficos
Publicado no:Cell Cycle
Main Authors: Li, Huixia, Zhou, Bo, Liu, Jiali, Li, Fang, Li, Yulong, Kang, Xiaomin, Sun, Hongzhi, Wu, Shufang
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis 2015
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615047/
https://ncbi.nlm.nih.gov/pubmed/26039714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1041686
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