Administration of progranulin (PGRN) triggers ER stress and impairs insulin sensitivity via PERK-eIF2α-dependent manner

Progranulin (PGRN) has recently emerged as an important regulator for glucose metabolism and insulin sensitivity. However, the direct effects of PGRN in vivo and the underlying mechanisms between PGRN and impaired insulin sensitivity are not fully understood. In this study, mice treated with PGRN fo...

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Bibliographische Detailangaben
Veröffentlicht in:Cell Cycle
Hauptverfasser: Li, Huixia, Zhou, Bo, Liu, Jiali, Li, Fang, Li, Yulong, Kang, Xiaomin, Sun, Hongzhi, Wu, Shufang
Format: Artigo
Sprache:Inglês
Veröffentlicht: Taylor & Francis 2015
Schlagworte:
Report
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4615047/
https://ncbi.nlm.nih.gov/pubmed/26039714
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15384101.2015.1041686
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