Progranulin causes adipose insulin resistance via increased autophagy resulting from activated oxidative stress and endoplasmic reticulum stress

BACKGROUND: Progranulin (PGRN) has recently emerged as an important regulator for insulin resistance. However, the direct effect of progranulin in adipose insulin resistance associated with the autophagy mechanism is not fully understood. METHODS: In the present study, progranulin was administered t...

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Detalhes bibliográficos
Publicado no:Lipids Health Dis
Main Authors: Guo, Qinyue, Xu, Lin, Li, Huixia, Sun, Hongzhi, Liu, Jiali, Wu, Shufang, Zhou, Bo
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2017
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282713/
https://ncbi.nlm.nih.gov/pubmed/28143512
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12944-017-0425-6
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