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Histone H4 expression is cooperatively maintained by IKKβ and Akt1 which attenuates cisplatin-induced apoptosis through the DNA-PK/RIP1/IAPs signaling cascade

While chromatin remodeling mediated by post-translational modification of histone is extensively studied in carcinogenesis and cancer cell’s response to chemotherapy and radiotherapy, little is known about the role of histone expression in chemoresistance. Here we report a novel chemoresistance mech...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Wang, Ruixue, Zheng, Xuelian, Zhang, Lei, Zhou, Bin, Hu, Huaizhong, Li, Zhiping, Zhang, Lin, Lin, Yong, Wang, Xia
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2017
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282510/
https://ncbi.nlm.nih.gov/pubmed/28139737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep41715
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