Increase of TREM2 during Aging of an Alzheimer’s Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis

Heterozygous missense mutations in the triggering receptor expressed on myeloid cells 2 (TREM2) have been reported to significantly increase the risk of developing Alzheimer’s disease (AD). Since TREM2 is specifically expressed by microglia in the brain, we hypothesized that soluble TREM2 (sTREM2) l...

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Veröffentlicht in:Front Aging Neurosci
Hauptverfasser: Brendel, Matthias, Kleinberger, Gernot, Probst, Federico, Jaworska, Anna, Overhoff, Felix, Blume, Tanja, Albert, Nathalie L., Carlsen, Janette, Lindner, Simon, Gildehaus, Franz Josef, Ozmen, Laurence, Suárez-Calvet, Marc, Bartenstein, Peter, Baumann, Karlheinz, Ewers, Michael, Herms, Jochen, Haass, Christian, Rominger, Axel
Format: Artigo
Sprache:Inglês
Veröffentlicht: Frontiers Media S.A. 2017
Schlagworte:
Neuroscience
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC5282474/
https://ncbi.nlm.nih.gov/pubmed/28197095
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2017.00008
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