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Chimeric human immunodeficiency virus type 1/type 2 reverse transcriptases display reversed sensitivity to nonnucleoside analog inhibitors.

Human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT), an important therapeutic target in the treatment of AIDS, is effectively inhibited by a class of nonnucleoside analog compounds that includes nevirapine (BI-RG-587) and tetrahydroimidazo[4,5,1-jk]-[1,4]benzodiazepin-2(1H)-one an...

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Publicado no:Proc Natl Acad Sci U S A
Principais autores: Shih, C K, Rose, J M, Hansen, G L, Wu, J C, Bacolla, A, Griffin, J A
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1991
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC52824/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/1719542/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.88.21.9878
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