A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors.

Several nonnucleoside inhibitors of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) have been described, including Nevirapine, thiobenzimidazolone (TIBO) derivatives, pyridinone derivatives such as L-697,661, and the bis(heteroaryl)piperazines (BHAPs). HIV-1 resistant to L-697...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Dueweke, T J, Pushkarskaya, T, Poppe, S M, Swaney, S M, Zhao, J Q, Chen, I S, Stevenson, M, Tarpley, W G
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC46583/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7685109/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.10.4713
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