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3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
HIV reverse transcriptase (RT) is one of the main targets for the action of anti-AIDS drugs. Many of these drugs [e.g., 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxyinosine (ddI)] are analogues of the nucleoside substrates used by the HIV RT. One of the main problems in anti-HIV therapy is the...
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Glavni autori: | , , , , , , , , , |
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Format: | Artigo |
Jezik: | Inglês |
Izdano: |
The National Academy of Sciences
1998
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Teme: | |
Online pristup: | https://ncbi.nlm.nih.gov/pmc/articles/PMC21370/ https://ncbi.nlm.nih.gov/pubmed/9689112 |
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