3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes

HIV reverse transcriptase (RT) is one of the main targets for the action of anti-AIDS drugs. Many of these drugs [e.g., 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxyinosine (ddI)] are analogues of the nucleoside substrates used by the HIV RT. One of the main problems in anti-HIV therapy is the...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Ren, Jingshan, Esnouf, Robert M., Hopkins, Andrew L., Jones, E. Yvonne, Kirby, Ian, Keeling, James, Ross, Carl K., Larder, Brendan A., Stuart, David I., Stammers, David K.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1998
Assuntos:	Biological Sciences
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21370/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9689112/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.16.9518
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