3′-Azido-3′-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes

HIV reverse transcriptase (RT) is one of the main targets for the action of anti-AIDS drugs. Many of these drugs [e.g., 3′-azido-3′-deoxythymidine (AZT) and 2′,3′-dideoxyinosine (ddI)] are analogues of the nucleoside substrates used by the HIV RT. One of the main problems in anti-HIV therapy is the...

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Detalhes bibliográficos
Main Authors: Ren, Jingshan, Esnouf, Robert M., Hopkins, Andrew L., Jones, E. Yvonne, Kirby, Ian, Keeling, James, Ross, Carl K., Larder, Brendan A., Stuart, David I., Stammers, David K.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences 1998
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21370/
https://ncbi.nlm.nih.gov/pubmed/9689112
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