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Humanized mouse models of clinical disease

Immunodeficient mice engrafted with functional human cells and tissues, i.e., “humanized mice”, have become increasingly important as small pre-clinical animal models for the study of human diseases. Since the description of immunodeficient mice bearing mutations in the IL2 receptor common gamma cha...

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Detalles Bibliográficos
Publicado en:Annu Rev Pathol
Autores principales: Walsh, Nicole, Kenney, Laurie, Jangalwe, Sonal, Aryee, Ken-Edwin, Greiner, Dale L., Brehm, Michael A., Shultz, Leonard D.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5280554/
https://ncbi.nlm.nih.gov/pubmed/27959627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1146/annurev-pathol-052016-100332
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